Lipogenesis in human adipose tissue

Lipogenesis in ovine adipose tissue in tissue culture.

Lipogenesis in brown adipose tissue and its regulation.

acids and ketone bodies in the circulation, and there is a need to conserve glucose because of the relatively low carbohydrate content of the milk (for review see Williamson, 1985). During this period of development, brown adipose tissue has a vital role in thermogenesis, and the level of GDP-binding to brown-fat mitochondria is considerably increased (Sundin & Cannon, 1980). The weight of inte...

Effect of propionate on lipogenesis in adipose tissue.

The metabolism of propionate in adipose tissue and its effect on lipogenesis was investigated. Fasting induced changes in propionate metabolism of adipose tissue, drastically reducing higher fatty acid synthesis and increasing glyceride-glyerol formation from low concentrations of propionate (0.25 mM). Propionate also promoted lipogenesis from acetate-1-(14)C in tissues of fasted rats, while it...

Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity.

To determine whether increased lipogenesis contributes to human obesity, we measured (postabsorptive state), in lean and obese subjects, lipid synthesis (deuterated water method) and the mRNA concentration (RT-competitive PCR) in subcutaneous adipose tissue of fatty acid synthase (FAS) and sterol regulatory element-binding protein (SREBP)-1c. Before energy restriction, obese subjects had an inc...

Insulin and rosiglitazone regulation of lipolysis and lipogenesis in human adipose tissue in vitro.

Lipolysis is an important process determining fuel metabolism, and insulin regulates this process in adipose tissue. The aim of this study was to investigate the long-term effects of insulin, an insulin enhancer (rosiglitazone [RSG]), and insulin in combination with RSG on the regulation of lipolysis and lipogenesis in human abdominal subcutaneous fat. Lipolysis and lipogenesis were assessed by...